Very mild, transient eye irritation. Primary skin irritation test showed
Dioctyl adipate is a very mild irritant, while diisopropyl adipate is
The Ames test for mutagenic potential of dioctyl adipate was negative.
The carcinogenicity assay of dioctyl adipate produced no side effects and was not carcinogenic to rats. Mouse study shows dose-related weight loss and higher incidence of hepatocellular carcinoma
Adenomas and carcinomas compared to controls. A Lifetime Study of Dioctyl Adipate
Does not cause skin tumors when given 10 mg weekly to back skin
mouse. The teratogenic potential of dioctyl adipate was reviewed.
The clinical evaluation of dioctyl adipate in the preparation showed the most,
When used in an occlusive state, erythema and papules are rare. No UV sensitization occurred. undiluted diisopropyl adipate
24-hour patch test, but moderately irritating at 21 days cumulative irritation
test. Formulated with up to 20% Diisopropyl Adipate for
For mild irritation, no sensitization, no photosensitivity. on the basis of
From the available data it can be concluded that dioctyl adipate and diisopropyl adipate
As safe as currently used in cosmetics.
Dioctyl adipate is produced by the reaction of adipic acid and 2-ethylhexanol
In the presence of esterification catalysts such as sulfuric acid and p-toluenesulfonic acid
acid or proprietary catalyst. Purification of the reaction product includes catalyst removal, caustic refining and steam distillation. '^.^) Diisopropyl adipate is prepared by the esterification of adipic acid with excess isopropanol. additional
Alcohol is removed by vacuum stripping, then the ester groups are refined and felted.
