The effects of adrenochrome might elucidate
The present study reports the oxidation of epinephrine (epinephrine), The effects of adrenochrome might elucidate. a neurotransmitter, by the lipid-compatible lipophilic Cr (VI) oxidant cetyltrimethyldichromate ammonium (CTADC). The kinetics of the reaction in organic medium in the presence of acetic acid was studied by UV-VIS spectroscopy. The reaction rate was determined by monitoring the oxidation product of epinephrine, epinephrine pigment, at 455 nm. This reaction is fractional with respect to CTADC and epinephrine. Acetic acid was found to slow down the reaction. According to the experimental results, a suitable ionic mechanism was proposed, that is, epinephrine was converted to epinephrine pigment by the intermediate, white chromium. The proposed reaction mechanism is also supported by the effects of solvent, temperature and surfactant on the reaction rate. The decrease in the reaction rate constant due to the increase in solvent polarity and hydrogen bond acceptor capacity indicates that the solvent has a transition state with lower polarity and stabilizes the reactants through strong intermolecular hydrogen bonds. The addition of surfactants, cationic, anion, and nonionic, reduced the reaction rate, and this delay can be explained by the partitioning of oxidants and substrates in different microheterogeneous media.
In a recent report on the reversibility of chlorpromazine in psychosis due to mescaline and D-lysergic acid diethylamine (LSD-25), careful attention was paid to clinical and EEG changes Although clinical changes in this reversal effect were immediate and significant, conventional EEG changes were minimal and difficult to assess. Another recent study noted that mescaline and LSD-25 did not activate temporal lobe epilepsy either clinically or on EEG
Because of these factors, it is hoped that in-depth electrographic studies will elucidate the effects of these drugs. It was also hoped that deep electrographic studies of the effects of epinephrine pigments would elucidate their role in inducing psychosis without self-awareness in volunteers and in increasing the role of paroxysmal discharges in the EEG of epileptic patients performed scalp EEG and depth electrographic examinations, respectively
