Tributyrin, a stable and rapidly absorbed prodrug of butyrate, potentiates the antiproliferative effect of dihydroxycholecalciferol in human colon cancer cells.
Tributyrin is a triglyceride naturally found in butter. It is an ester composed of butyric acid and glycerin. [1] It is used, among other things, as an ingredient in making margarine. It is found in butter and can be described as a liquid fat with a pungent taste.
Tributyrin is also used in microbiology laboratories to identify Moraxella catarrhalis. [2]
Tributyrin, a stable and rapidly absorbed prodrug of butyrate, potentiates the antiproliferative effect of dihydroxycholecalciferol in human colon cancer cells.
In the livestock industry, alternatives to antibiotics are needed due to the increase in antibiotic resistance. In this competition, tributyrin showed the ability to promote gut health, regulate gut microbiota, and improve protein digestibility, thereby enhancing growth performance. However, while the mode of action of tributyrin on intestinal epithelial cells has been partially explained, its effects on lipid and protein metabolism still need to be investigated. This article provides information on the effects of tributyrin on production traits, blood parameters, fecal microbiota and fecal protein excretion in weaned piglets.
The aim of this study was to investigate the effects of tributyrin supplementation on production traits, key metabolic parameters and gut microbiota in weaned piglets. 120 hybrid piglets (Large White×Landrace) were randomly divided into two experimental groups (6 pens per group; 10 piglets per pen): control group (CTRL) receiving basal diet and tributyrin group (TRIB) Receive a basal diet supplemented with 0.2% tributyrin.
