Multiple sclerosis (MS) (MS). A prescription-only nasal spray containing both 9-delta-tetrahydrocannabinol (THC) and Cannabidiol (Sativex, GW Pharmaceuticals) has been shown to be effective in improving pain, muscle tightness, and urination frequency in people with MS. Outside of the United States, this product is used in over 25 countries. However, there is inconclusive evidence on the efficacy of cannabidiol for symptoms of multiple sclerosis when used alone. Some preliminary research suggests that using a cannabidiol spray under the tongue may improve pain and muscle tightness in MS patients, but not muscle spasms, tiredness, bladder control, mobility, or well-being and quality of life.
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